anti-CXCR3 antibody product blog
Tags: Antibody; Polyclonal Antibody; CXCR3; anti-CXCR3 antibody;
The CXCR3 cxcr3 (Catalog #MBS176866) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-CXCR3 Antibody reacts with Human, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s CXCR3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Researchers should empirically determine the suitability of the CXCR3 cxcr3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The CXCR3 cxcr3 product has the following accession number(s) (GI #2829400) (NCBI Accession #P49682.2) (Uniprot Accession #P49682). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-CXCR3 Antibody with the following immunoassay(s):
Immunohistochemistry (IHC) (Anti-CXCR3 Picoband antibody, MBS176866-1.JPG
IHC(P): Rat Kidney Tissue )
Immunohistochemistry (IHC) (Anti-CXCR3 Picoband antibody, MBS176866-2.JPG
IHC(P): Human Tonsil Tissue )
Immunohistochemistry (IHC) (Anti-CXCR3 Picoband antibody, MBS176866-3.JPG
IHC(P): Human Lung Cancer Tissue )
Testing Data (Anti-CXCR3 Picoband antibody, MBS176866-4.jpg
All lanes: Anti-CXCR3(MBS176866) at 0.5ug/ml
Lane 1: Colo320 Whole Cell Lysate at 40ug
Lane 2: SGC Whole Cell Lysate at 40ug
Predicted bind size: 41KD
Observed bind size: 41KD
)
Description: Rabbit IgG polyclonal antibody for C-X-C chemokine receptor type 3(CXCR3) detection. Tested with WB, IHC-P in Human, Rat.
Background: Chemokine receptor CXCR3 is a Galphai protein-coupled receptor in the CXC chemokine receptor family. Other names for CXCR3 are G protein-coupled receptor 9 (GPR9) and CD183. It is mapped to Xq13.1. CXCR3 is expressed on malignant B cells from chronic lymphoproliferative disorders, particularly in patients with CLL, and represents a fully functional receptor involved in chemotaxis of malignant B lymphocytes. It is found that in the absence of known etiologic agents, CXCR3 represents a novel target for therapeutic interference early in type 1 diabetes. CXCR3 signaling is associated with MG pathogenesis and proposed that and CXCR3 may serve as novel drug targets to treat MG. CXCR3A and CXCR3B are involved in the chemotactic and vascular effects of CXCL4L1.
Immunogen: E Coli-derived human CXCR3 recombinant protein (Position: M1-L368). Human CXCR3 shares 86% amino acid (aa) sequence identity with both mouse and rat CXCR3. Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CXCR3 are readily searchable from our website. Different antibodies against the same target such as CXCR3 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.