|The CYLD cyld (Catalog #MBS177928) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-CYLD Antibody reacts with Human, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s CYLD can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).
Western Blot Concentration: 0.1-0.5ug/ml. Researchers should empirically determine the suitability of the CYLD cyld for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CYLD cyld product has the following accession number(s) (GI #109637774) (NCBI Accession #NP_001035814.1) (Uniprot Accession #Q9NQC7). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-CYLD Antibody with the following immunoassay(s):
Western Blot (WB) (Anti- CYLD Picoband antibody, MBS177928, Western blotting
All lanes: Anti CYLD (MBS177928) at 0.5ug/ml
Lane 1: Rat Testis Tissue Lysate at 50ug
Lane 2: Rat Brain Tissue Lysate at 50ug
Lane 3: HELA Whole Cell Lysate at 40ug
Predicted bind size: 107KD
Observed bind size: 107KD )
Description: Rabbit IgG polyclonal antibody for Ubiquitin carboxyl-terminal hydrolase CYLD(CYLD) detection. Tested with WB in Human;Rat.
Background: CYLD is localized on the long arm of chromosome 16. This gene encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Immunogen: E Coli-derived human CYLD recombinant protein (Position: D618-K956). Human CYLD shares 97.6% and 97.9% amino acid (aa) sequence identity with mouse and rat CYLD, respectively.
Ig Type: Rabbit IgG. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CYLD are readily searchable from our website. Different antibodies against the same target such as CYLD may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. CYLD also interacts with the following gene(s): BCL3, DDX58, IKBKG, RIPK1, SQSTM1, TNFRSF1A, TRAF2, TRAF6, TRAIP. Blood, Bone, Bone Marrow, Brain, Kidney, Liver, Lung, Skin, Thymus, Vascular tissues are correlated with this protein. Adenocarcinoma, Carcinoma, Hepatocellular, Cell Transformation, Neoplastic, Familial cylindromatosis, Gastrointestinal Diseases, Inflammation, Leukemia, Liver Diseases, Liver Neoplasms, Necrosis are some of the diseases may be linked to Anti-CYLD Antibody.