anti-DAB2 antibody product blog
Tags: Antibody; Polyclonal Antibody; DAB2; anti-DAB2 antibody;
The DAB2 dab2 (Catalog #MBS2524612) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DAB2 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s DAB2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC).WB: 1:500-1:2000
IHC: 1:50-1:200. Researchers should empirically determine the suitability of the DAB2 dab2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The DAB2 dab2 product has the following accession number(s) (GI #148491082) (NCBI Accession #NP_001334.2). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the DAB2 Polyclonal Antibody with the following immunoassay(s):
Western Blot (WB) (Western Blot analysis of Hela cell using DAB2 Polyclonal Antibody at dilution of 1:350)
Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human tonsil using DAB2 Polyclonal Antibody at dilution of 1:30)
Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human thyroid cancer using DAB2 Polyclonal Antibody at dilution of 1:30)
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Immunogen: Recombinant protein of human DAB2
Calculated Molecular Weight: 82kDa. Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing DAB2 are readily searchable from our website. Different antibodies against the same target such as DAB2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. DAB2 also interacts with the following gene(s): CYP11B2, GRB2, LDLR, LRP2, MYO6, SMAD2. Adenocarcinoma, Breast Neoplasms, Carcinoma, Cardiovascular Diseases, Kidney Diseases, Lung Neoplasms, Neoplasm Metastasis, Nervous System Diseases, Ovarian Neoplasms, Prostatic Neoplasms are some of the diseases may be linked to DAB2 Polyclonal Antibody.