anti-Daxx antibody product blog
Tags: Antibody; Polyclonal Antibody; Daxx; anti-DAXX antibody;
The Daxx daxx (Catalog #MBS840383) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Daxx Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Daxx can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).Western blot: 1:200. Researchers should empirically determine the suitability of the Daxx daxx for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The Daxx daxx product has the following accession number(s) (GI #215422388) (NCBI Accession #NP_001135441.1) (Uniprot Accession #Q9UER7). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Daxx Antibody with the following immunoassay(s):
Testing Data
Polyclonal Antibody to detect Daxx in human, mouse and rat samples
Background: Apoptosis can be induced by certain cytokines including TNF and Fas ligand through binding to their respective death domain (DD) containing receptors, TNFR1 and Fas. Cell death signals can then be transduced by DD-containing adapter molecules and members of the caspase family. A novel DD-containing adapter molecule was recently cloned from mouse, human and monkey and designated Daxx. Daxx binds to the Fas DD and activates a FADD-independent death pathway that involves the stress activated c-Jun NH2-terminal kinase (JNK). Daxx activates the JNK kinase kinase ASK1 that is also known as MAPKKK5. FADD and Daxx activate two independent pathways downstream of Fas. Daxx mRNA is widely expressed in fetal and adult tissues with the highest amounts being found in the testis.
Immunogen: Synthetic peptide in the middle of the sequence (BV-M28)
Positive Control: Western blot: Rat Kidneylysate. Handling: The antibody solution should be gently mixed before use. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Daxx are readily searchable from our website. Different antibodies against the same target such as Daxx may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Bone, Brain, Heart, Kidney, Liver, Lung, Muscle, Prostate, Vascular tissues are correlated with this protein. The following patways have been known to be associated with this gene. Daxx also interacts with the following gene(s): ATRX, DMAP1, ETS1, HSF1, HSPB1, MAP3K5, PAX5, TP53.