|The DFFB dffb (Catalog #MBS623642) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DFF40, IN (CAD I18, DNA Fragmentation Factor, Caspase Activated Deoxyribonuclease, CPAN) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s DFF40, IN can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the DFFB dffb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The DFFB dffb product has the following accession number(s) (GI #544063489) (NCBI Accession #NP_001269598.1) (Uniprot Accession #O76075). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A mouse DNase that causes DNA fragmentation was identified recently and designated CAD for caspase activated deoxyribonuclease (1,2). The human homologue of mouse CAD was more recently identified by three groups independently and termed CPAN, DFF40, and human CAD, respectively, (3-5). DFF45/ICAD is the inhibitory protein of DFF40/CAD (1,2,6) and forms complex with DFF40/CAD. Upon cleavage of DFF45/ICAD by activated caspase, DFF40/CAD is released and activated and eventually causes the degradation of DNA in the nuclei. Activation of DFF40/CAD, which causes DNA degradation, is the hallmark of apoptotic cell death. SOURCE: Rabbit anti-DFF40 (IN) polyclonal antibody was raised against a peptide corresponding to amino acids 203 to 218 of human DFF40 (4, 5).
Immunogen: Peptide corresponding to amino acids 203 to 218 of human DFF40 (4, 5). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing DFFB are readily searchable from our website. Different antibodies against the same target such as DFFB may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Bone, Brain, Connective Tissue, Kidney, Liver, Lung, Skin, Testis, Vascular tissues are correlated with this protein. Adenocarcinoma, Carcinoma, Cardiovascular Diseases, Cognition Disorders, Liver Diseases, Lymphoma, Necrosis, Neoplasms, Neoplasms, Experimental, Nervous System Diseases are some of the diseases may be linked to DFF40, IN (CAD I18, DNA Fragmentation Factor, Caspase Activated Deoxyribonuclease, CPAN).