anti-DIO2 antibody product blog
Tags: Antibody; DIO2; Polyclonal Antibody; anti-DIO2 antibody;
The DIO2 dio2 (Catalog #MBS2520620) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DIO2 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s DIO2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB).WB: 1:200-1:1000. Researchers should empirically determine the suitability of the DIO2 dio2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The DIO2 dio2 product has the following accession number(s) (GI #38969818) (NCBI Accession #AAH63118.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the DIO2 Polyclonal Antibody with the following immunoassay(s):
Western Blot (WB) (Western Blot analysis of Mouse brain tissue using DIO2 Polyclonal Antibody at dilution of 1:200)
The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3, 3\', 5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3\' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.
Immunogen: Synthetic peptide of human DIO2
Calculated Molecular Weight: 31kDa. Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing DIO2 are readily searchable from our website. Different antibodies against the same target such as DIO2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Cardiovascular Diseases, Fatty Liver, Hypertension, Hypertrophy, Inflammation, Kidney Diseases, Nervous System Diseases, Thyroid Diseases, Weight Gain, Weight Loss are some of the diseases may be linked to DIO2 Polyclonal Antibody. The following patways have been known to be associated with this gene.