anti-DMPK antibody product blog
Tags: Antibody; DMPK; anti-DMPK antibody; Polyclonal Antibody;
The DMPK dmpk (Catalog #MBS610305) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DMPK (Dystrophy Myotonic Protein Kinase Protein) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s DMPK can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 0.1-1ug/ml
Western Blot: 1-3ug/ml. Researchers should empirically determine the suitability of the DMPK dmpk for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The DMPK dmpk product has the following accession number(s) (GI #71051932) (Uniprot Accession #Q09013). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Myotonic dystrophy (DM) is a highly variable multisystemic disease that leads to muscle wasting, myotonia, cataracts, heart block and neurobehavioral abnormalities. Myotonic dystrophy is caused by a polymorphic expansion of trinucleotide (CTG) repeats in the 3\' untranslated region (UTR) of a c-AMP-dependent protein kinase (myotonic dystrophy protein kinase, DMPK) gene. Strong nucleosome positioning signals created by this expanded repeat cause a reduction in gene expression within the region. The molecular weight of DMPK is 80kD and it is expressed in the cytosolic fraction of skeletal muscles. DMPK is localized at the gap junction level in the heart, specifically in the intercalated disc. Heart transcripts of the DMPK (DMRB15) gene are subject to alternative splicing in both human and mouse.
Immunogen: Synthetic peptide from the C-terminal region of the mouse Myotonic Dystrophy Protein kinase (DMPK) protein. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing DMPK are readily searchable from our website. Different antibodies against the same target such as DMPK may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Cataract, Diabetes Mellitus, Fatty Liver, Hepatitis, Inflammation, Insulin Resistance, Kidney Diseases, Liver Diseases, Muscular Diseases, Neoplasms are some of the diseases may be linked to DMPK (Dystrophy Myotonic Protein Kinase Protein). Brain, Embryonic Tissue, Eye, Heart, Intestine, Kidney, Liver, Lung, Muscle, Spleen tissues are correlated with this protein. DMPK also interacts with the following gene(s): CELF1, HSPB2, PLN, SP1.