|The DNASE2 dnase2 (Catalog #MBS610101) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Deoxyribonuclease II (DNase II) reacts with Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s Deoxyribonuclease II can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA).
Suitable for use in ELISA.
Dilution: ELISA: 1:10,000-50,000 using 50-100ng control peptide/well. Researchers should empirically determine the suitability of the DNASE2 dnase2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The DNASE2 dnase2 product has the following accession number(s) (GI #14275880) (Uniprot Accession #O00115). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Deoxyribonuclease II (Dnase II, EC.126.96.36.199) is one of the two Dnase present in mammalian tissues and biological fluids. Dnase II hydrolyzes DNA to 3\'-phosphoryl oligonucleotides under acidic conditions. Dnase II is also known as "acid Dnase". It has preference of for dsDNA. Dnase II has been implicated in internucleosomal cleavage of chromatin to generate DNA fragments or ladder, a hallmark of apoptosis. Dnase II (mouse 353aa; human 360aa, chromosome 19p13.2-q13.4) is a lysosomal enzyme present in most tissues. Dnase Ii is synthesized as a pro-enzyme (signal peptide aa1-16, propeptide region of 91-aa, and 253-aa mature protein (aa110-353) and processed to produce active enzyme containing 2- chains of ~32 and 12kD. Dnase II has no significant sequence homology with Dnase I.
Immunogen: A synthetic peptide corresponding to 17aa near the C-terminus of mouse Dnase II, conjugated to KLH. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing DNASE2 are readily searchable from our website. Different antibodies against the same target such as DNASE2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Arthritis, Inflammation, Vasculitis are some of the diseases may be linked to Deoxyribonuclease II (DNase II). Blood, Brain, Kidney, Liver, Lung, Thyroid tissues are correlated with this protein.