anti-DNMT3B antibody product blog
Tags: Antibody; DNMT3B; anti-DNMT3B antibody; Polyclonal Antibody; DNA Methyltransferase 3B;
The DNMT3B dnmt3b (Catalog #MBS610504) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DNA Methyltransferase 3B (Dnmt 3B) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s DNA Methyltransferase 3B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP).Suitable for use in Western Blot and Immunoprecipitation. Researchers should empirically determine the suitability of the DNMT3B dnmt3b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The DNMT3B dnmt3b product has the following accession number(s) (GI #6118092) (Uniprot Accession #Q2PJS8). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The Dnmt3 family members, Dnmt3a and Dnmt3b, are strongly expressed in ES cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. Recently, it has been shown that naturally occurring mutations of Dnmt3b gene occurs in patients with a rare autosomal recessive disorder, termed ICF (immunodeficiency, centromeric instability, and facial anomalies) syndrome.
Immunogen: This antibody was raised against residues 4-101 of the human DNMT3b protein. Positive Control: HCT116 cell lysates. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing DNMT3B are readily searchable from our website. Different antibodies against the same target such as DNMT3B may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Bone, Bone Marrow, Brain, Embryonic Tissue, Kidney, Liver, Lung, Prostate, Testis tissues are correlated with this protein.