|The DRD2 drd2 (Catalog #MBS618028) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Dopamine Receptor, D2L, D2LR reacts with Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Dopamine Receptor, D2L, D2LR can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).
Suitable for use in ELISA, Western Blot.
Dilution: Western Blot: 1:500-1:2500
ELISA: 1:5,000-25,000. Researchers should empirically determine the suitability of the DRD2 drd2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The DRD2 drd2 product has the following accession number(s) (GI #17986270) (NCBI Accession #NP_057658.2) (Uniprot Accession #P14416). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Dopamine is an endogenous catecholamine that influences many cellular activities, including behavior, hormone synthesis and release, blood pressure and intracellular ion transport. A family of at least 5 Dopamine Receptors (DR) genes, D1-D5, have been identified based upon the amino acid identity, pharmacological specificity and effector responses. DR have been classified into either the D1-like (D1, D1B, and D5) or D2-like (D2, D3, and D4). The two isoforms of D2R, D2 long (D2L) and short D2S), are encoded by splice variants of a single gene and differ only by the presence of an additional 29aa in the intracellular domain 3 of the D2 long form. It may play a role in the coupling of the receptor to G-proteins. All members of this family have similar structure and contain 7 putative transmembrane domains. A given cell or tissue may express more than one DR. Specific radioligands do not exist that can differentiate between these DR. Therefore, specific antibodies are needed to distinguish, localize, and document changes in DR levels in cells and tissues under various normal and pathological conditions.
Immunogen: A 27 AA Peptide (Control peptide) sequence from the rat D2 long form, within the cytoplasmic loop # 3, (2). The 27 AA sequence is unique to the long form and it is not found in the D2 short or other receptor isoform. The peptide was coupled to KLH. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing DRD2 are readily searchable from our website. Different antibodies against the same target such as DRD2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.