anti-E6 antibody product blog
Tags: Antibody; Polyclonal Antibody; anti-E6 antibody; papillomavirus type 16 Protein E6;
The E6 e6 (Catalog #MBS1489053) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human papillomavirus type 16 Protein E6 polyclonal Antibody reacts with Human Papillomavirus Type 16 and may cross-react with other species as described in the data sheet. MyBioSource\'s papillomavirus type 16 Protein E6 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). Researchers should empirically determine the suitability of the E6 e6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The E6 e6 product has the following accession number(s) (GI #9627104) (NCBI Accession #NP_041325.1) (Uniprot Accession #P03126). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6P targets several other substrates to degradation via the proteasome including host NFX1-91, a repressor of human telomerase reverse transcriptase (hTERT). The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization. Other cellular targets including Bak, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis. E6 also inhibits immune response by interacting with host IRF3 and TYK2. These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.
Storage Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate: Non-conjugated. Immunogen: Recombinant human papillomavirus type 16 Protein E6 protein
Species: Human papillomavirus type 16
Research Area: Microbiology
Target Names: E6. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing E6 are readily searchable from our website. Different antibodies against the same target such as E6 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene.