anti-EGFR antibody product blog
Tags: Antibody; anti-EGFR antibody; EGFR; Polyclonal Antibody; Epidermal Growth Factor Receptor;
The EGFR egfr (Catalog #MBS625249) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Epidermal Growth Factor Receptor, phosphorylated (Tyr1173) (erbB, EGFR) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Epidermal Growth Factor Receptor can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1:1000. Researchers should empirically determine the suitability of the EGFR egfr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The EGFR egfr product has the following accession number(s) (GI #326467049) (Uniprot Accession #P00533). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Epidermal Growth Factor Receptor, also known as ErbB-1 (EGFR, a 185kD glycoprotein) is a transmembrane tyrosine kinase that regulates a variety of biological responses ranging from mitogenesis to stress signaling. The EGFR consists of a large extracellular domain, a single transmembrane domain and a cytoplasmic domain that exhibits kinase activity. Upon binding of EGF to the extracellular domain, the receptor undergoes dimerization and becomes phosphorylated on several tyrosine residues within the cytoplasmic domain. Autophosphorylation of tyrosine 1173 creates a major binding site for the protein tyrosine phosphatase SHP-1, which can dephosphorylate the EGFR and thereby block EGFR-induced activation of the ERK1&2 signaling pathway.
Immunogen: Synthetic phosphopeptide corresponding to human EGFR that contains tyrosine 1173. Species sequence homology: mouse and rat. Positive Control: A431 cells +/- EGF. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing EGFR are readily searchable from our website. Different antibodies against the same target such as EGFR may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. EGFR also interacts with the following gene(s): CBL, CTNNB1, EGF, ERBB2, ERBB3, ERBB4, GRB2, MAPK1, MET, STAT3. Adenocarcinoma, Breast Neoplasms, Carcinoma, Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Kidney Diseases, Lung Diseases, Lung Neoplasms, Neoplasms are some of the diseases may be linked to Epidermal Growth Factor Receptor, phosphorylated (Tyr1173) (erbB, EGFR).