|The EIF4EBP1 eif4ebp1 (Catalog #MBS629977) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The EIF4EBP1, phosphorylated (Ser65) (Eukaryotic Translation Initiation Factor 4E-binding Protein 1, 4E-BP1, eIF4E-binding Protein 1, Phosphorylated Heat- and Acid-stable Protein Regulated by Insulin 1, PHAS-I) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s EIF4EBP1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC).
Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Dilution: ELISA: 1:4000
Western Blot: 1:500-1:1000
Immunohistochemistry: 1:50-1:100. Researchers should empirically determine the suitability of the EIF4EBP1 eif4ebp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The EIF4EBP1 eif4ebp1 product has the following accession number(s) (GI #4758258) (NCBI Accession #NP_004086.1) (Uniprot Accession #Q13541). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
EIF4EBP1 is one member of a family of translation repressor proteins. It directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5\' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
Immunogen: Synthetic phosphopeptide corresponding to human EIF4EBP1 around the phosphorylation site of serine 65 (R-N-pS-P-V). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing EIF4EBP1 are readily searchable from our website. Different antibodies against the same target such as EIF4EBP1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. EIF4EBP1 also interacts with the following gene(s): AKT1, ATM, EIF4E, MAPK1, MTOR, RPS6KB1. Breast Neoplasms, Carcinoma, Hypertrophy, Immune System Diseases, Insulin Resistance, Leukemia, Male Urogenital Diseases, Neoplasms, Tuberous Sclerosis, Urogenital Neoplasms are some of the diseases may be linked to EIF4EBP1, phosphorylated (Ser65) (Eukaryotic Translation Initiation Factor 4E-binding Protein 1, 4E-BP1, eIF4E-binding Protein 1, Phosphorylated Heat- and Acid-stable Protein Regulated by Insulin 1, PHAS-I).