anti-Endoplasmic Reticulum Associated Amyloid Beta Binding Protein antibody product blog
Tags: Antibody; Polyclonal Antibody; Endoplasmic Reticulum Associated Amyloid Beta Binding Protein; anti-Endoplasmic Reticulum Associated Amyloid Beta Binding Protein antibody;
The Endoplasmic Reticulum Associated Amyloid Beta Binding Protein n/a (Catalog #MBS615689) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Endoplasmic Reticulum Associated Amyloid Beta Binding Protein (ERAB) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Endoplasmic Reticulum Associated Amyloid Beta Binding Protein can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).Suitable for use in Western Blot and ELISA.
Dilution: Western Blot: 1:1000-1:5000. Detects ~27kD protein in the brain
ELISA: 1:10,000-1:100,000 using 50-100ng of control peptide/well. Researchers should empirically determine the suitability of the Endoplasmic Reticulum Associated Amyloid Beta Binding Protein n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
An intracellular protein termed ERAB (262aa, Endoplasmic reticulum associated Ab binding protein on chromosome X) has been cloned and linked with Ab neurotoxicity. ERAB has structural homology with short-chain alcohol dehydrogenases (hydroxysteroid dehydrogenases and acetyl-CoA reductases). Interestingly, ERAB localizes to endoplasmic reticulum despite the absence of a classical transmembrane sequence. However, in the presence of Ab, ERAB-Ab complex translates to the inner plasma membrane. Alzheimer patients have strong ERAB activity. Normal brains have virtually no ERAB. In addition, Ab neurotoxicity can be reduced by blocking ERAB.
Immunogen: Synthetic peptide corresponding to a 14aa sequence from the middle portion of human ERAB. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Endoplasmic Reticulum Associated Amyloid Beta Binding Protein are readily searchable from our website. Different antibodies against the same target such as Endoplasmic Reticulum Associated Amyloid Beta Binding Protein may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.