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anti-Erbb2 antibody product blog

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Posted on 2015-10-05 13:52:44 by mybiosource_staff
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Tags: Antibody; Polyclonal Antibody; ERBB2; anti-ERBB2 antibody; Mouse Erbb2;
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The Erbb2 erbb2 (Catalog #MBS9209362) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Mouse Erbb2 Antibody (P1236) reacts with Mouse, rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Erbb2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA).
WB~~1:2000. Researchers should empirically determine the suitability of the Erbb2 erbb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The Erbb2 erbb2 product has the following accession number(s) (GI #54873610) (NCBI Accession #NP_001003817.1) (Uniprot Accession #P70424). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:


Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Mouse Erbb2 Antibody (P1236) with the following immunoassay(s):
Western Blot (WB) (All lanes : Anti-Erbb2 Antibody (P1236) at 1:2000 dilution
Lane 1: mouse ovary lysates
Lane 2: rat lung lysates

Lysates/proteins at 20 ug per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution

Predicted band size : 139 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.)
Western Blot (WB) Erbb2.

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity).

Antigen Source: HUMAN. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Erbb2 are readily searchable from our website. Different antibodies against the same target such as Erbb2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Bone, Brain, Heart, Kidney, Liver, Lung, Mammary Gland, Ovary, Skin, Stomach tissues are correlated with this protein. Erbb2 also interacts with the following gene(s): Ctnnb1, Egfr, Erbb2ip, Erbb3, Grb2, Hsp90aa1, Nrg1, Shc1, Src, Stat3.
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