|The ErbB4 n/a (Catalog #MBS280014) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-Human V-Erb An Erythroblastic Leukemia Viral Oncogene Homolog 4 (ErbB4) polyclonal antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s V-Erb An Erythroblastic Leukemia Viral Oncogene Homolog 4 can be used in a range of immunoassay formats including, but not limited to, Western Blot Analysis (WB), Immunohistochemistry (IHC), ELISA (EIA). Researchers should empirically determine the suitability of the ErbB4 n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
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ErbB4 is a member of the epidermal growth factor receptor subfamily. ERBB4 is a single-pass type I transmembrane protein with multiple furin-like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins-2 and -3, heparin-binding EGF-like growth factor and betacellulin. Ligand binding induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Storage Buffer: PBS, pH: 7.20, 1% BSA, 0.02% Sodium azide.
Immunogen: Recombinant protein, corresponding to the N-term of human ERBB4. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ErbB4 are readily searchable from our website. Different antibodies against the same target such as ErbB4 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.