|The ESPL1 espl1 (Catalog #MBS2530129) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ESPL1 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s ESPL1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC).
IHC: 1:25-1:100. Researchers should empirically determine the suitability of the ESPL1 espl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The ESPL1 espl1 product has the following accession number(s) (GI #148877887) (NCBI Accession #AAI45845.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the ESPL1 Polyclonal Antibody with the following immunoassay(s):
Western Blot (WB) (Western Blot analysis of Raji cell using ESPL1 Polyclonal Antibody at dilution of 1:500)
Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human thyroid cancer using ESPL1 Polyclonal Antibody at dilution of 1:40)
Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human cervical cancer using ESPL1 Polyclonal Antibody at dilution of 1:40)
Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 or STAG2 in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 by ESPL1, or separase, which initiates the final separation of sister chromatids.
Immunogen: Synthetic peptide of human ESPL1
Calculated Molecular Weight: 233kDa. Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ESPL1 are readily searchable from our website. Different antibodies against the same target such as ESPL1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Bone, Bone Marrow, Brain, Eye, Kidney, Lung, Lymph Node, Mammary Gland, Pancreas, Thymus tissues are correlated with this protein. ESPL1 also interacts with the following gene(s): Bub1b, Cdc20, Plk1, Pttg1, Rad21, Rec8, Smc3, Stag1. The following patways have been known to be associated with this gene. Breast Neoplasms, Carcinoma, Transitional Cell, Cell Transformation, Neoplastic, Disease Models, Animal, Infertility, Female, Infertility, Male, Lung Neoplasms, Neoplasms, Experimental, Ovarian Diseases, Urinary Bladder Neoplasms are some of the diseases may be linked to ESPL1 Polyclonal Antibody.