|The ESX1 esx1 (Catalog #MBS150856) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ESX1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s ESX1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF).
ESX1 antibody can be used for detection of ESX1 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL. Researchers should empirically determine the suitability of the ESX1 esx1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The ESX1 esx1 product has the following accession number(s) (GI #116241356) (NCBI Accession #Q8N693.3) (Uniprot Accession #Q8N693). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the ESX1 Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of ESX1 in human testis tissue lysate with ESX1 antibody at (A) 1 and (B) 2 μg/mL.)
Immunofluorescence (IF) (Immunofluorescence of ESX1 in human testis tissue with ESX1 antibody at 20 μg/mL.)
Immunohistochemistry (IHC) (Immunohistochemistry of ESX1 in human testis tissue with ESX1 antibody at 2.5 μg/mL.)
ESX1 Antibody: Homeobox proteins are transcription factors that contain a helix-turn-helix DNA binding domain termed the homeodomain. ESX1 is an X-linked homeobox gene primarily expressed in the placenta and testis and contains two functional domains: the homeodomain and the proline-rich domain. During embryogenesis, ESX1 is expressed in the extraembryonic tissues, including the endoderm of the visceral yolk sac, the ectoderm of the chorion and the labyrinthine trophoblast of the chorioallantoic placenta. ESX1 can act like a transcriptional repressor to the human oncogene K-ras and treatment of human cancer cells with an ESX1 protein fragment containing the homeodomain reduces the tumorgenicity of cells containing oncogenic K-ras mutations, suggesting ESX1 may be useful as a therapeutic treatment for these cancers.
Immunogen: ESX1 antibody was raised against a 19 amino acid synthetic peptide near the center of human ESX1.
Buffer: ESX1 Antibody is supplied in PBS containing 0.02% sodium azide. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ESX1 are readily searchable from our website. Different antibodies against the same target such as ESX1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.