anti-EXOSC2 antibody product blog
Tags: Antibody; EXOSC2; anti-EXOSC2 antibody; Polyclonal Antibody;
The EXOSC2 exosc2 (Catalog #MBS9211654) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The EXOSC2 Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s EXOSC2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA).WB~~1:1000. Researchers should empirically determine the suitability of the EXOSC2 exosc2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The EXOSC2 exosc2 product has the following accession number(s) (GI #19923403) (NCBI Accession #NP_055100.2) (Uniprot Accession #Q13868). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the EXOSC2 Antibody (N-term) with the following immunoassay(s):
Western Blot (WB) (EXOSC2 Antibody(N-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the EXOSC2 antibody detected the EXOSC2 protein (arrow).)
Non-catalytic component of the RNA exosome complex which has 3\'->5\' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding \'pervasive\' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3\' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7.
Antigen Type: Synthetic Peptide
Crown Antibody: Yes. Antigen Source: Human. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing EXOSC2 are readily searchable from our website. Different antibodies against the same target such as EXOSC2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.