|The FADD fadd (Catalog #MBS629271) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FADD, phosphorylated (Ser191) (FADD Protein, FAS-associating Death Domain-containing Protein, FAS-associated Death Domain Protein, Mediator of rEceptor Induced Toxicity, Fadd, Mort1) reacts with Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s FADD can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC).
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100. Researchers should empirically determine the suitability of the FADD fadd for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The FADD fadd product has the following accession number(s) (GI #48145593) (Uniprot Accession #Q13158). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
FADD is an apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Ser191 of human mFADD (KLH). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing FADD are readily searchable from our website. Different antibodies against the same target such as FADD may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Bone, Brain, Kidney, Liver, Lung, Muscle, Prostate, Skin, Vascular tissues are correlated with this protein. The following patways have been known to be associated with this gene. FADD also interacts with the following gene(s): CASP10, CASP8, CFLAR, FAS, FASLG, RIPK1, TNFRSF10A, TNFRSF10B, TRADD, TRAF2. Adenocarcinoma, Breast Neoplasms, Drug Toxicity, Genital Diseases, Male, Inflammation, Leukemia, Lung Diseases, Necrosis, Neoplasms, Neoplasms, Experimental are some of the diseases may be linked to FADD, phosphorylated (Ser191) (FADD Protein, FAS-associating Death Domain-containing Protein, FAS-associated Death Domain Protein, Mediator of rEceptor Induced Toxicity, Fadd, Mort1).