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anti-FAIM antibody product blog

Posted on 2015-08-19 00:09:06 by mybiosource_staff
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Tags: Antibody; Polyclonal Antibody; anti-FAIM antibody; FAIM;
The FAIM faim (Catalog #MBS150757) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FAIM Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s FAIM can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB).
FAIM antibody can be used for detection of FAIM by Western blot at 5 - 10 mug/mL. Researchers should empirically determine the suitability of the FAIM faim for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The FAIM faim product has the following accession number(s) (GI #8922536) (NCBI Accession #NP_060617) (Uniprot Accession #Q9NVQ4). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the FAIM Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of FAIM in human spleen tissue lysate with FAIM antibody at (A) 5 and (B) 10 μg/mL.)
Western Blot (WB) FAIM.

FAIM Antibody: The susceptibility of primary splenic B cells to Fas-mediated apoptosis is regulated in a receptor-specific fashion. Terminal effectors of B cell Fas-resistance include the known anti-apoptotic proteins Bcl-xL, FLIP, and a recently identified protein termed FAIM. This molecule is broadly expressed in various tissues and exists in at least three isoforms. It is thought that resistance to Fas killing via increased expression of FAIM protects foreign antigen-specific B cells during interactions with FasL-bearing T cells whereas autoreactive B cells are deleted via Fas-dependent cytotoxicity. More recent results have indicated that FAIM interacts with both Trk and p75 neurotrophin receptor and may play a role in promoting neurite outgrowth in different neuronal systems by a mechanism involving the activation of NF-κB and the Ras-ERK pathway.

Conjugate: Unconjugated
Immunogen: FAIM antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human FAIM.
Buffer: FAIM Antibody is supplied in PBS containing 0.02% sodium azide. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing FAIM are readily searchable from our website. Different antibodies against the same target such as FAIM may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.
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