anti-FANCD2 antibody product blog
Tags: Antibody; Polyclonal Antibody; FANCD2; anti-FANCD2 antibody; Fanconi anemia D2;
The FANCD2 fancd2 (Catalog #MBS615028) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Fanconi anemia D2, phosphorylated (Ser222) (FA4, FACD, FAD, FAD2, FANCD2, Fanconi anemia Complementation Group D, Fanconi Pancytopenia Type 4) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Fanconi anemia D2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).Suitable for use in Western Blot. Researchers should empirically determine the suitability of the FANCD2 fancd2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The FANCD2 fancd2 product has the following accession number(s) (GI #66528888) (NCBI Accession #NP_001018125.1) (Uniprot Accession #Q9BXW9). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Fanconi anemia (FANC) is a human autosomal-recessive cancer susceptibility disorder characterized by congenital defects, progressive bone marrow failure, and cellular hypersensitivity to mitomycin C (MMC). The FANC subunit D2 protein is vital for cellular resistance to DNA cross-linking and the arrest of DNA synthesis after ionizing radiation. DNA damage activates the monoubiquitination of FANCD2, targeting nuclear foci containing the BRCA1 protein.
Immunogen: A synthetic peptide made to the human FANCD2 sequence (residues 217-226), surrounding a phosphorylated serine (222). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing FANCD2 are readily searchable from our website. Different antibodies against the same target such as FANCD2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Bone, Bone Marrow, Brain, Kidney, Liver, Lung, Lymph, Lymph Node, Ovary tissues are correlated with this protein. Anemia, Ataxia, Breast Neoplasms, Carcinoma, Carcinoma, Squamous Cell, Chromosome Aberrations, Congenital Abnormalities, Fanconi Anemia, Leukemia, Myeloid, Neoplasms are some of the diseases may be linked to Fanconi anemia D2, phosphorylated (Ser222) (FA4, FACD, FAD, FAD2, FANCD2, Fanconi anemia Complementation Group D, Fanconi Pancytopenia Type 4). The following patways have been known to be associated with this gene. FANCD2 also interacts with the following gene(s): BRCA1, BRCA2, FANCC.