|The FEZ1 fez1 (Catalog #MBS150572) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FEZ1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s FEZ1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB).
FEZ1 antibody can be used for the detection of FEZ1 by Western blot at 1 mug/mL. Despite its predicted molecular weight, FEZ1 will often run at higher molecular weight in SDS-PAGE. Researchers should empirically determine the suitability of the FEZ1 fez1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The FEZ1 fez1 product has the following accession number(s) (GI #13431526) (NCBI Accession #Q99689.1) (Uniprot Accession #Q99689). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the FEZ1 Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of FEZ1 in SK-N-SH cell lysate with FEZ1 antibody at 1 μg/mL in the (A) presence and (B) absence of blocking peptide.)
FEZ1 Antibody: Similar to its C. elegans homolog UNC-76, mammalian FEZ1, an abundant membrane protein and protein kinase C (PKC)-Z substrate, is involved in axonal guidance. Following phosphorylation by PKC-Z, FEZ1 translocates from the plasma membrane to the cytoplasm. FEZ1 is then able to interact with a number of proteins involved in axonal outgrowth and cellular transport such as DISC1, a candidate gene for schizophrenia, as well as kinesin-1, a microtubule-based motor protein. FEZ1 also interacts with proteins involved in transcriptional regulation and chromatin remodeling, suggesting that FEZ1 may have nuclear regulatory functions in addition to those for neuronal development. At least two distinct isoforms of FEZ1 are known to exist.
Immunogen: FEZ1 antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human FEZ1.
Buffer: FEZ1 Antibody is supplied in PBS containing 0.02% sodium azide. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing FEZ1 are readily searchable from our website. Different antibodies against the same target such as FEZ1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.