anti-FLCN antibody product blog
Tags: Antibody; Polyclonal Antibody; anti-FLCN antibody; FLCN;
The FLCN flcn (Catalog #MBS9205508) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FLCN Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s FLCN can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC).WB~~1:1000. Researchers should empirically determine the suitability of the FLCN flcn for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The FLCN flcn product has the following accession number(s) (GI #21389403) (NCBI Accession #NP_653207.1) (Uniprot Accession #Q8NFG4). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the FLCN Antibody (Center) with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of FLCN Antibody (Center) in CEM cell line lysates (35ug/lane). FLCN (arrow) was detected using the purified Pab.)
Immunohistochemistry (IHC) (Formalin-fixed and paraffin-embedded human lung carcinoma reacted with FLCN Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
FLCN may play a role in the pathogenesis of an uncommon form of kidney cancer through its association with an inherited disorder of the hair follicle (fibrofolliculomas). FLCN may be a tumor suppressor. May be involved in colorectal tumorigenesis. It may be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways.
Antigen Type: Synthetic Peptide. Antigen Source: HUMAN. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing FLCN are readily searchable from our website. Different antibodies against the same target such as FLCN may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. FLCN also interacts with the following gene(s): CCND1, FNIP1, FNIP2, PKP4, TFE3. The following patways have been known to be associated with this gene. Birt-Hogg-Dube Syndrome, Breast Neoplasms, Cardiovascular Diseases, Disease Models, Animal, Hyperplasia, Kidney Diseases, Liver Diseases, Liver Neoplasms, Nervous System Diseases, Weight Loss are some of the diseases may be linked to FLCN Antibody (Center). Blood, Bone, Brain, Kidney, Liver, Ovary, Placenta, Skin, Testis, Uterus tissues are correlated with this protein.