|The Fox3 n/a (Catalog #MBS645197) is an Antibody produced from Chicken and is intended for research purposes only. The product is available for immediate purchase. The Fox3 (Fox-3, Fox-1 Homolog C, Hexaribonucleotide-binding Protein 3, Hrnbp3, Neuronal Nuclei, NeuN, RNA Binding Protein Fox-1 Homolog 3, RBFOX3) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s Fox3 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Immunocytochemistry (ICC).
Suitable for use in Immunohistochemistry and Immunocytochemistry.
Dilution: Immunohistochemistry: 1:1000. Researchers should empirically determine the suitability of the Fox3 n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The Fox3 n/a product has the following accession number(s) (GI #380354042) (NCBI Accession #CCG23556.1) (Uniprot Accession #H8X6E5). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Fox3 is one of a family of 3 mammalian Fox homologues. Fox was discovered in C. elegans as a gene involved in sex determination, and the name Fox is an acronym of "Feminizing locus on X". The Fox protein and its 3 mammalian homologues are all about 46kD proteins each of which includes a central highly conserved RRM type RNA recognition motif, which corresponds to a small ~70aa structure consisting of 4 beta strands and two alpha-helices. An alternate name for Fox 3 is hexaribonucleotide binding protein 3, and these proteins are believed to have a role in the regulation of mRNA splicing.
Much interest has focused on Fox3 as this protein corresponds to NeuN, a neuronal nuclear antigen. NeuN antibody has become very widely used as a robust marker of neurons and neuronal stem cells. Fox3 is therefore a protein which has a funciton in RNA splicing and is expressed heavily and specifically in neuronal nuclei.
Immunogen: Synthetic peptide corresponding to the Fox-3 gene product, shared between the human (NP_001076044) and mouse (NP_001020102) sequences, conjugated to KLH. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Fox3 are readily searchable from our website. Different antibodies against the same target such as Fox3 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.