|The FRS2 frs2 (Catalog #MBS610569) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FRS2 alpha, phosphorylated (Tyr196) (Fibroblast Growth Factor Receptor Substrate 2, RS2, Suc-associated Neurotrophic Factor-induced Tyrosine-phosphorylated Target, SNT) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s FRS2 alpha can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).
Suitable for use in Western Blot
Dilution: Western Blot: 1:1000 Incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4 degree C with gentle shaking, overnight. Researchers should empirically determine the suitability of the FRS2 frs2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The FRS2 frs2 product has the following accession number(s) (GI #110347408) (NCBI Accession #NP_006645.3) (Uniprot Accession #Q8WU20). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Fibroblast growth factor receptor substrate 2 (FRS2, also called Suc-associated neurotrophic factor-induced tyrosine -phosphorylated target or SNT) participates in the transmission of extracellular signals from the fibroblast growth factor receptor (FGFR). Activation of the FGFR leads to tyrosyl phosphorylation of FRS2. Two FRS2 family members have been identified: FRS2-alpha (SNT1) and FRS2-beta (SNT2), which can directly bind to a range of activated receptor tyrosine kinases (RTKs) and become the substrate for these RTKs. Once they are tyrosyl phosphorylated, they can recruit SH2 domain-containing proteins including Grb2 and SHP-2, mediating a downstream biochemical and biological response. Tyrosine 436 was shown to be required for efficient SHP-2 recruitment, whereas tyrosine 196 functions as docking sites for Grb2-Sos complexes.
Immunogen: Synthetic phosphopeptide corresponding to residues surrounding tyrosine 196 of human FRS2-alpha. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing FRS2 are readily searchable from our website. Different antibodies against the same target such as FRS2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. FRS2 also interacts with the following gene(s): CBL, CRK, FGFR1, FGFR2, GRB2, MAPK1, PTPN11, RET, SOS1, SRC. Blood, Brain, Embryonic Tissue, Kidney, Liver, Lung, Muscle, Prostate, Stomach, Vascular tissues are correlated with this protein.