|The FZD6 fzd6 (Catalog #MBS2523715) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FZD6 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s FZD6 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC).
IHC: 1:100-1:300. Researchers should empirically determine the suitability of the FZD6 fzd6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The FZD6 fzd6 product has the following accession number(s) (GI #257471001) (NCBI Accession #NP_001158088.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the FZD6 Polyclonal Antibody with the following immunoassay(s):
Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using FZD6 Polyclonal Antibody at dilution 1:60)
Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human gastric cancer tissue using FZD6 Polyclonal Antibody at dilution 1:60)
This gene represents a member of the \'frizzled\' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.
Immunogen: Synthetic peptide of human FZD6. Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing FZD6 are readily searchable from our website. Different antibodies against the same target such as FZD6 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. FZD6 also interacts with the following gene(s): CTHRC1, DVL1, DVL2, DVL3, FZD5, SFRP1, WNT11, WNT16, WNT3A, WNT4. Abnormalities, Multiple, Breast Neoplasms, Cell Transformation, Neoplastic, Disease Models, Animal, Hyperplasia, Inflammation, Liver Neoplasms, Lung Neoplasms, Nervous System Malformations, Neural Tube Defects are some of the diseases may be linked to FZD6 Polyclonal Antibody.