|The G6PD g6pd (Catalog #MBS2521603) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The G6PD Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s G6PD can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the G6PD g6pd for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The G6PD g6pd product has the following accession number(s) (GI #116242483) (NCBI Accession #P11413.4). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the G6PD Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of extracts of various cell lines, using G6PD antibody.)
Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded human esophageal cancer using G6PD antibody at dilution of 1:100 (400x lens).)
Glucose-6-phosphate dehydrogenase (G6PD) catalyses the first and rate-limiting step of the pentose phosphate pathway (1). The NADPH generated from this reaction is essential to protect cells from oxidative stress (1). Recent studies have shown that p53 interacts with G6PD and inhibits its activity, therefore suppressing glucose consumption through the pentose phosphate pathway (2). In cancer cells with p53 mutations, the increased glucose consumption is directed towards increased biosynthesis, which is critical for cancer cell proliferation (2).
Immunogen: Recombinant protein of human G6PD
Observed Molecular Weight: 59kDa. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-46971 / sc-67165. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing G6PD are readily searchable from our website. Different antibodies against the same target such as G6PD may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Anemia, Anemia, Hemolytic, Anemia, Hemolytic, Congenital Nonspherocytic, Brain Diseases, Favism, Glucosephosphate Dehydrogenase Deficiency, Hemolysis, Liver Diseases, Nervous System Diseases, Poisoning are some of the diseases may be linked to G6PD Antibody. The following patways have been known to be associated with this gene. Blood, Bone, Bone Marrow, Brain, Kidney, Liver, Lung, Muscle, Skin, Vascular tissues are correlated with this protein.