anti-GABRG2 antibody product blog
Tags: Antibody; Polyclonal Antibody; GABRG2; anti-GABRG2 antibody; GABA Receptor A, gamma2;
The GABRG2 gabrg2 (Catalog #MBS627298) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-GABA Receptor A, gamma2 (Gamma-aminobutyric Acid Receptor Type A gamma Subunit, GABRA) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s GABA Receptor A, gamma2 can be used in a range of immunoassay formats including, but not limited to, ELISA; Western Blot.Western Blot: 1-2ug/ml using ECL technique.
ELISA: 0.5-1ug/ml; Control peptide can be used to coat ELISA plates at 1ug/ml. Researchers should empirically determine the suitability of the GABRG2 gabrg2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The GABRG2 gabrg2 product has the following accession number(s) (GI #38788155) (NCBI Accession #NP_944494.1) (Uniprot Accession #P18507). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
GABA (g-amino butyric acid) is the most abundant neurotransmitter in mammalian brain. GABA exerts its effects through ionotropic ligand-gated GABAA, GABAC and GABAB receptors (GABABRs). A family of GABA-A receptors subtypes exists, which are generated by alternative splicing of alpha 1-6, beta 1-4, gamma 1-4, delta, epsilon, pie, theta, and rho1-3 to form a heteromeric (pentameric) protein complexes. Various GABA-A subunits show distinct patterns of temporal and spatial expression that may imply its tissue specific physiological role (1). GABA A (GAA) receptor proteins (450-627 aa) are characterized by the presence of a cleavable signal peptide, a large extracellular N-terminus, 3 TM (transmembrane) domains, a large cytoplasmic domain followed by TM4 and C-terminal extracellular domain. The regions between TM3-4 and the large cytoplasmic loop are least conserved among various GAA subunits, which may confer subunit specific functionality. GAA genes are distributed as clusters throughout the human genome (chromosomes 4, 5, 15, and X; delta subunit on chromosome 1). GAA in the brain are the targets of many clinically important drugs.
Immunogen: Recombinant GAG2 fragment 189-299aa. Location: ~Extracellular domain.
Source Information: Human. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing GABRG2 are readily searchable from our website. Different antibodies against the same target such as GABRG2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.