anti-GCH1 antibody product blog
Tags: Antibody; Polyclonal Antibody; GCH1; anti-GCH1 antibody;
The GCH1 gch1 (Catalog #MBS9409514) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GCH1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s GCH1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC).Western blotting: 1:200-1:1000
Immunohistochemistry: 1:5-1:20. Researchers should empirically determine the suitability of the GCH1 gch1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The GCH1 gch1 product has the following accession number(s) (GI #4503949) (NCBI Accession #NP_000152.1) (Uniprot Accession #P30793). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the GCH1 Antibody with the following immunoassay(s):
Testing Data (Gel: 12%SDS-PAGE Lysates (from left to right): Human fetal liver tissue and hela cell Amount of lysate: 60ug per lane Primary antibody: 1/200 dilution Secondary antibody dilution: 1/8000 Exposure time: 15 minutes)
Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin-embedded Human brain tissue using at dilution 1/15.)
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.
Immunogen Type: Peptide
Immunogen Description: Synthetic peptide corresponding to a region derived from internal residues of human GTP cyclohydrolase 1. Target Name: GCH1. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing GCH1 are readily searchable from our website. Different antibodies against the same target such as GCH1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Blood, Bone, Brain, Embryonic Tissue, Kidney, Liver, Lung, Muscle, Skin, Uterus tissues are correlated with this protein. GCH1 also interacts with the following gene(s): GCHFR, PTS. Cardiovascular Diseases, Death, Disease Models, Animal, Dystonia, Dystonia, Dopa-responsive, Heart Diseases, Hypertension, Inflammation, Nervous System Diseases, Pain are some of the diseases may be linked to GCH1 Antibody.