anti-GJA1 antibody product blog
Tags: Antibody; Polyclonal Antibody; GJA1; anti-GJA1 antibody;
The GJA1 gja1 (Catalog #MBS9408540) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GJA1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s GJA1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC).Western blotting: 1:500 - 1:2000
Immunohistochemistry: 1:50 - 1:100. Researchers should empirically determine the suitability of the GJA1 gja1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The GJA1 gja1 product has the following accession number(s) (GI #4504001) (NCBI Accession #NP_000156.1) (Uniprot Accession #P17302). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the GJA1 Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of extracts of HeLa cell lines, using GJA1 antibody.)
Connexin 43 (Cx43) is a member of the large family of gap junction proteins. Connexins assemble as a hexamer and are transported to the plasma membrane to create a hemichannel that can associate with hemichannels on nearby cells to create cell-to-cell channels. Clusters of these channels assemble to make gap junctions. Gap junction communication is important in development and regulation of cell growth. Phosphorylation of Cx43 is important in regulating assembly and function of gap junctions (1,2). Ser368 of Cx43 is phosphorylated by protein kinase C (PKC) after activation by phorbol esters, which decreases cell-to-cell communication (3). Src can interact with and phosphorylate Cx43 to alter gap junction communication (4,5).
Immunogen Type: Recombinant Protein
Immunogen Description: Recombinant protein of human GJA1. Target Name: GJA1. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing GJA1 are readily searchable from our website. Different antibodies against the same target such as GJA1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Arrhythmias, Cardiac, Cardiomegaly, Disease Models, Animal, Heart Diseases, Hypertrophy, Infertility, Male, Inflammation, Lung Neoplasms, Necrosis, Oculodentodigital Dysplasia are some of the diseases may be linked to GJA1 Antibody. GJA1 also interacts with the following gene(s): CDH2, CTNNB1, JUN, MAPK1, MAPK3, SRC, TJP1, UBQLN4. Bone, Brain, Embryonic Tissue, Heart, Lung, Nerve, Ovary, Skin, Uterus, Vascular tissues are correlated with this protein.