anti-GLE1 antibody product blog
Tags: Antibody; Polyclonal Antibody; Gle1; anti-GLE1 antibody;
The GLE1 gle1 (Catalog #MBS150335) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Gle1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Gle1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF).Gle1 antibody can be used for detection of Gle1 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 5 mug/mL. Researchers should empirically determine the suitability of the GLE1 gle1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The GLE1 gle1 product has the following accession number(s) (GI #51317384) (NCBI Accession #NP_001003722) (Uniprot Accession #Q53GS7). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Gle1 Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of Gle1 in mouse brain tissue lysate with Gle1 antibody at (A) 1 and (B) 2 μg/mL.)
Immunohistochemistry (IHC) (Immunohistochemistry of Gle1 in mouse brain tissue with Gle1 antibody at 2.5 μg/mL.)
Immunofluorescence (IF) (Immunofluorescence of gle1 in mouse brain tissue with gle1 antibody at 5 μg/mL.)
Gle1 Antibody: The proper expression of gene products in eukaryotic cells relies on efficient transport of mRNA molecules out of the nucleus. Gle1 is an essential mRNA export factor in both human and yeast cells. It associates with the nuclear pore complex (NPC) through hCG1 and NUP155 in mammalian cells and in conjunction with inositol hexakisphosphate (IP6), stimulates Dbp5, a member of the DEAD-box helicase family, triggering mRNP remodeling and facilitating RNA export from the nucleus. Recent evidence suggests that mutations in Gle1 causing defects in mRNA export can result in human disease. At least three isoforms of Gle1 are known to exist.
Conjugate: Unconjugated
Immunogen: Gle1 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human Gle1.
Buffer: Gle1 Antibody is supplied in PBS containing 0.02% sodium azide. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing GLE1 are readily searchable from our website. Different antibodies against the same target such as GLE1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.