|The GRK4 grk4 (Catalog #MBS2527406) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GRK4 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s GRK4 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC).
IHC: 1:50-1:200. Researchers should empirically determine the suitability of the GRK4 grk4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The GRK4 grk4 product has the following accession number(s) (GI #558472850) (NCBI Accession #NP_005298.2). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the GRK4 Polyclonal Antibody with the following immunoassay(s):
Western Blot (WB) (Western Blot analysis of Jurkat cell using GRK4 Polyclonal Antibody at dilution of 1:500)
Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human tonsil using GRK4 Polyclonal Antibody at dilution of 1:30)
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.
Immunogen: Recombinant protein of human GRK4
Calculated Molecular Weight: 67kDa. Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing GRK4 are readily searchable from our website. Different antibodies against the same target such as GRK4 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Cardiovascular Abnormalities, Cardiovascular Diseases, Congenital Abnormalities, Heart Diseases, Hyperplasia, Hypertension, Hyperthyroidism, Kidney Diseases, Pre-Eclampsia, Proteinuria are some of the diseases may be linked to GRK4 Polyclonal Antibody. The following patways have been known to be associated with this gene. Brain, Eye, Heart, Kidney, Lung, Parathyroid, Testis tissues are correlated with this protein.