anti-GRM1 antibody product blog
Tags: Antibody; Polyclonal Antibody; anti-GRM1 antibody; GRM1;
The GRM1 grm1 (Catalog #MBS9408789) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GRM1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s GRM1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC).Western blotting: 1:500-1:2000
Immunohistochemistry: 1:15-1:50. Researchers should empirically determine the suitability of the GRM1 grm1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The GRM1 grm1 product has the following accession number(s) (GI #493798972) (NCBI Accession #NP_000829) (Uniprot Accession #Q13255). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the GRM1 Antibody with the following immunoassay(s):
Testing Data (Gel: 8%SDS-PAGE
Lysate: 60ug Hela cell
Primary antibody: 1/125
Secondary antibody dilution: 1/8000
Exposure time: 1 minute)
Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue at dilution 1/15.)
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions.
Immunogen Type: Peptide
Immunogen Description: Synthetic peptide corresponding to a region derived from internal residues of human glutamate receptor, metabotropic 1. Target Name: GRM1. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing GRM1 are readily searchable from our website. Different antibodies against the same target such as GRM1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.