|The HAND2 hand2 (Catalog #MBS627670) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HAND2, CT (Heart and Neural Crest Derivatives Expressed 2, Heart- and Neural Crest Derivatives-expressed Protein 2, Class A Basic Helix-loop-helix Protein 26, bHLHa26, Deciduum Heart Autonomic Nervous System and Neural Crest Derivatives-expressed Protein reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s HAND2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC).
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:200
Immunohistochemistry: 1:50-1:100. Researchers should empirically determine the suitability of the HAND2 hand2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The HAND2 hand2 product has the following accession number(s) (GI #12545384) (NCBI Accession #NP_068808.1) (Uniprot Accession #P61296). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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HAND2 belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development.
Immunogen: Synthetic peptide selected from the C-terminal region of human HAND2 (KLH). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing HAND2 are readily searchable from our website. Different antibodies against the same target such as HAND2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Adrenal Gland, Bone, Brain, Embryonic Tissue, Heart, Intestine, Mouth, Nerve, Placenta, Uterus tissues are correlated with this protein. HAND2 also interacts with the following gene(s): COPS5, EP300, GATA4, HAND1, HEY2, PHOX2A, TCF3. Carcinoma, Embryonal, Cleft Palate, Colitis, Craniofacial Abnormalities, Heart Defects, Congenital, Hypertension, Pulmonary, Jaw Abnormalities, Limb Deformities, Congenital, Neoplasms, Neural Tube Defects are some of the diseases may be linked to HAND2, CT (Heart and Neural Crest Derivatives Expressed 2, Heart- and Neural Crest Derivatives-expressed Protein 2, Class A Basic Helix-loop-helix Protein 26, bHLHa26, Deciduum Heart Autonomic Nervous System and Neural Crest Derivatives-expressed Protein.