anti-HDAC3 antibody product blog
Tags: Antibody; Polyclonal Antibody; HDAC3; anti-HDAC3 antibody;
The HDAC3 hdac3 (Catalog #MBS176146) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-HDAC3 antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s HDAC3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunohistochemistry (IHC) Formalin, Immunocytochemistry ICC. Researchers should empirically determine the suitability of the HDAC3 hdac3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The HDAC3 hdac3 product has the following accession number(s) (GI #3334210) (NCBI Accession #O15379.2) (Uniprot Accession #O15379). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-HDAC3 antibody with the following immunoassay(s):
Immunohistochemistry (IHC) (Anti-HDAC3 antibody, MBS176146, IHC(P)
IHC(P): Human Intestinal Cancer Tissue )
Immunohistochemistry (IHC) (Anti-HDAC3 antibody, MBS176146, IHC(P)
IHC(P): Human Lung Cancer Tissue
)
Immunohistochemistry (IHC) (Anti-HDAC3 antibody, MBS176146, IHC(P)
IHC(P): Rat Intestine Tissue )
Immunohistochemistry (IHC) (Anti-HDAC3 antibody, MBS176146, IHC(F)
IHC(F): Mouse Brain Tissue )
Immunocytochemistry (ICC) (Anti-HDAC3 antibody, MBS176146, ICC
ICC: A549 Cell )
Western Blot (WB) (Anti-HDAC3 antibody, MBS176146, Western blotting
Lane 1: Rat Stomach Tissue Lysate
Lane 2: Rat Testis Tissue Lysate
Lane 3: MCF-7 Cell Lysate
Lane 4: HELA Cell Lysate
Lane 5: JURKAT Cell Lysate
Lane 6: SKOV Cell Lysate
)
Description: Rabbit IgG polyclonal antibody for Histone deacetylase 3(HDAC3) detection. Tested with WB, IHC-P, IHC-F, ICC in Human, Mouse, Rat.
Background: HDAC3(HISTONE DEACETYLASE 3) is a member of the histone deacetylase/acuc/apha family of proteins that is an enzyme that in humans is encoded by the HDAC3 gene. The HDAC3 gene is mapped to 5q31.3. HDAC3 has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. The protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. And this gene is regarded as a potential tumor suppressor gene. HDAC3 has an open reading frame of 428 amino acids and shares 53% amino acid identity with HDAC1 and 52% with HDAC2. The catalytic domain of HDAC4 interacts with HDAC3 via the transcriptional corepressor NCOR2. All experimental conditions leading to the suppression of HDAC4 binding to NCOR2 and to HDAC3 resulted in loss of enzymatic activity associated with HDAC4. HDAC3 recruitment to the genome displays a circadian rhythm in mouse liver.
Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human HDAC3 (411-428aa NEFYDGDHDNDKESDVEI), identical to the related rat and mouse sequences.