anti-Histone H4, Dimethyl Symmetric antibody product blog
Tags: Antibody; Polyclonal Antibody; Histone H4, Dimethyl Symmetric; anti-Histone H4, Dimethyl Symmetric antibody;
The Histone H4, Dimethyl Symmetric n/a (Catalog #MBS6010099) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Histone H4, Dimethyl Symmetric (Arg3) (HIST1H4A, H4/A, H4FA, HIST1H4B, H4/I, H4FI, HIST1H4C, H4/G, H4FG, HIST1H4D, H4/B, H4FB, HIST1H4E, H4/J, H4FJ, HIST1H4F, H4/C, H4FC, HIST1H4H, H4/H, H4FH, HIST1H4I, H4/M, H4FM, HIST1H4J, H4/E, H4FE, HIST1H4K, H4/D, H4 reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Histone H4, Dimethyl Symmetric can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Gel Shift Assay (GS/EMSA).Suitable for use in Western Blot, Dot Blot, Chromatin Immunoprecipitation and Immunocytochemistry. Researchers should empirically determine the suitability of the Histone H4, Dimethyl Symmetric n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Histones are highly conserved proteins that serve as the structural scaffold for the organization of nuclear DNA into chromatin. The four core histones, H2A, H2B, H3, and H4, assemble into an octamer (2 molecules of each). Histones are modified post-translationally by the actions of enzymes in both the nucleus and cytoplasm. These modifications, which include acetylation, phosphorylation, methylation, and ubiquitin-ation, occur predominantly on the N-terminal and C-terminal tails that extend beyond the nucleosome core particle. Arginine modifications of histones proteins are mediated by two classes of protein arginine methyltransferases (PRMTs), class I and II. Class I PRMTs place two methyl groups on the one nitrogen atom of the arginine guanidino group, resulting in an asymmetric modification. In contrast class II PRMTs place two methyl groups on two nitrogen atoms of the guanidino group producing a symmetric dimethylation. Although there are exceptions, asymmetric modifications are typically associated with transcription activation while symmetric modifications are most commonly associated with transcriptional repression.
Immunogen: Synthetic linear peptide corresponding to human Histone H4 (KLH). Positive Control: Includes normal rabbit IgG and primers specific for human B-globin. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Histone H4, Dimethyl Symmetric are readily searchable from our website. Different antibodies against the same target such as Histone H4, Dimethyl Symmetric may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.