|The HMGCL hmgcl (Catalog #MBS6001087) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HMGCL (Hydroxymethylglutaryl-CoA Lyase, Mitochondrial, HMG-CoA Lyase, HL, 3-hydroxy-3-methylglutarate-CoA Lyase) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s HMGCL can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP).
Suitable for use in Western Blot and Immunoprecipitation. Researchers should empirically determine the suitability of the HMGCL hmgcl for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The HMGCL hmgcl product has the following accession number(s) (GI #260654708) (NCBI Accession #NP_001159531.1) (Uniprot Accession #P35914). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful. The amino acid sequence is listed below:
MAAMRKALPR RLVGLASLRA VSTSSMGTLP KRVKIVEVGP RDGLQNEKNI VSTPVKIKLI DMLSEAGLSV IETTSFVSPK WVPQMGDHTE VLKGIQKFPG INYPVLTPNL KGFEAAVAAG AKEVVIFGAA SELFTKKNIN CSIEESFQRF DAILKAAQSA NISVRGYVSC ALGCPYEGKI SPAKVAEVTK KFYSMGCYEI SLGDTIGVGT PGIMKDMLSA VMQEVPLAAL AVHCHDTYGQ ALANTLMALQ MGVSVVDSSV AGLGGCPYAQ GASGNLATED LVYMLEGLGI HTGVNLQKLL EAGNFICQAL NRKTSSKVAQ ATCKL.
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The protein encoded by this gene belongs to the HMG-CoA lyase family. It is a mitochondrial enzyme that catalyzes the final step of leucine degradation and plays a key role in ketone body formation. Mutations in this gene are associated with HMG-CoA lyase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Immunogen: Full length human HMGCL, aa1-325 (NP_000182.2). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing HMGCL are readily searchable from our website. Different antibodies against the same target such as HMGCL may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Disease Models, Animal, Fatty Liver, HMG CoA lyase deficiency, Inflammation, Neoplasms, Nervous System Diseases are some of the diseases may be linked to HMGCL (Hydroxymethylglutaryl-CoA Lyase, Mitochondrial, HMG-CoA Lyase, HL, 3-hydroxy-3-methylglutarate-CoA Lyase). Adipose Tissue, Blood, Brain, Connective Tissue, Heart, Kidney, Liver, Muscle, Prostate, Skin tissues are correlated with this protein. The following patways have been known to be associated with this gene. HMGCL also interacts with the following gene(s): ACAT1, HMGCS1, HMGCS2, OXCT1.