|The HNF1 alpha hnf1a (Catalog #MBS835587) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HNF1 alpha antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s HNF1 alpha can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin, Western Blot (WB).
WB: 1:500-1:3000. Researchers should empirically determine the suitability of the HNF1 alpha hnf1a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The HNF1 alpha hnf1a product has the following accession number(s) (GI #256542297) (NCBI Accession #NP_000536.5) (Uniprot Accession #P20823). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the HNF1 alpha antibody with the following immunoassay(s):
Immunohistochemistry (IHC) (Immunohistochemical staining of paraffin-embedded A549 Xenograft using HNF1 alpha antibody at a dilution of 1:100)
Western Blot (WB) (Western blot analysis of 30 ug of whole cell lysate (A: Hep G2) using a 7.5 % SDS PAGE gel and HNF1 alpha antibody at a dilution of 1:1000)
Affinity purified Rabbit polyclonal HNF1 alpha antibody.
Biological Significance: The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5\'-GTTAATNATTAAC-3\'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 and also can result in the appearance of hepatic adenomas. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing HNF1 alpha are readily searchable from our website. Different antibodies against the same target such as HNF1 alpha may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Adenoma, Liver Cell, Carcinoma, Hepatocellular, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Disease Models, Animal, Inflammation, Kidney Diseases, Liver Diseases, Liver Neoplasms, Neoplasms, Experimental are some of the diseases may be linked to HNF1 alpha antibody. Eye, Intestine, Kidney, Liver, Mixed, Stomach tissues are correlated with this protein. HNF1 alpha also interacts with the following gene(s): CREBBP, CTNNB1, DYRK1B, HDAC1, HNF4A, HNF4G, ONECUT1, PCBD1, PDX1, SLC2A2.