anti-HPSE antibody product blog
Tags: Antibody; Monoclonal Antibody; HPSE ; anti-HPSE antibody;
The HPSE hpse (Catalog #MBS2542177) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The HPSE Monoclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s HPSE can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA).WB: 1:1000-1:10000
IHC: 1:200-1:1000
IF: 1:50-1:500. Researchers should empirically determine the suitability of the HPSE hpse for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The HPSE hpse product has the following accession number(s) (GI #148746204) (NCBI Accession #NP_001092010.1) (Uniprot Accession #Q9Y251). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the HPSE Monoclonal Antibody with the following immunoassay(s):
Western Blot (WB) (Western Blot analysis of HepG2 cells using HPSE Monoclonal Antibody at dilution of 1:2000)
HPSE(Heparanase) is also named as HEP, HPA, HPA1, HPR1, HPSE1, HSE1 and belongs to the glycosyl hydrolase 79 family. It is an endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. HPSE is essential in the disassembly of the extracellular matrix (ECM) by invading cells. It has 3 isoforms produced by alternative splicing with the molecular weight of 61 kDa, 55 kDa and 53 kDa. The full length protein has six glycosylation sites. The cleavage of the 65 kDa form leads to the generation of a linker peptide, and 8 kDa and 50 kDa products. The active form, the 8/50 kDa heterodimer, is resistant to degradation and glycosylation of the 50 kDa subunit appears to be essential for its solubility.
Immunogen: Fusion protein of HPSE. Buffer: PBS with 0.02% sodium azide, 50% glycerol, PH7.3
Conjugation: Unconjugated. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing HPSE are readily searchable from our website. Different antibodies against the same target such as HPSE may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. HPSE also interacts with the following gene(s): GPC3, HSPG2, SDC1. Breast Neoplasms, Carcinoma, Hepatocellular, Disease Models, Animal, Inflammation, Kidney Diseases, Liver Neoplasms, Lung Neoplasms, Melanoma, Neoplasm Invasiveness, Neoplasm Metastasis are some of the diseases may be linked to HPSE Monoclonal Antibody.