anti-HTRA2 antibody product blog
Tags: Antibody; Polyclonal Antibody; HTRA2; anti-HTRA2 antibody; OMI;
The HTRA2 htra2 (Catalog #MBS150947) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The OMI Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s OMI can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF).OMI antibody can be used for detection of OMI by Western blot at 0.5 to 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2 mug/mL. For immunofluorescence start at 20 mug/mL. Researchers should empirically determine the suitability of the HTRA2 htra2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The HTRA2 htra2 product has the following accession number(s) (GI #5870865) (NCBI Accession #AAB94569) (Uniprot Accession #O43464). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the OMI Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of OMI in U937 lysate with Omi antibody at (A) 0.5, (B) 1, and (C) 2 μg/mL.)
Immunohistochemistry (IHC) (Immunohistochemistry of OMI in human liver tissue with OMI antibody at 2 μg/mL.)
Immunofluorescence (IF) (Immunofluorescence of OMI in Human Liver cells with OMI antibody at 20 μg/mL.)
OMI Antibody: Inhibitor of apoptosis proteins (IAPs) were initially identified in baculoviruses as proteins that inhibit apoptosis of the host cells to allow time for viral replication. Cellular homologues containing at least one baculoviral IAP repeat (BIR) motif essential for their anti-apoptosis activity have been identified in yeasts and higher organisms and often act by binding and inhibiting processed caspases. The activity of these proteins can be modulated by the expression of proteins such as Smac/DIABLO and XAF-1 which displace or prevent the binding of caspases by IAPs. Recently, a mitochondrial serine protease termed Omi/HtrA2 has been found to bind IAPs. Similar to Smac, Omi possesses a conserved IAP-binding motif, but acts to cleave IAPs to irreversibly inactivate IAPs and promote apoptosis.
Conjugate: Unconjugated
Immunogen: OMI antibody was raised against a peptide corresponding to 16 amino acids near the C-terminus of human Omi.
Buffer: OMI Antibody is supplied in PBS containing 0.02% sodium azide. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing HTRA2 are readily searchable from our website. Different antibodies against the same target such as HTRA2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.