Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource  rightarrow Polyclonal Antibody Blog  rightarrow anti-IGF1 antibody  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Blogs moreseparator
separator
 • anti-Zap-70 antibody blog
 • anti-CDH15 antibody blog
 • anti-NUCB2 antibody blog
 • anti-CDKN1B antibody blog
 • anti-Nell2 antibody blog
 • anti-POT1 antibody blog
 • anti-CDC37 antibody blog
 • anti-LMOD1 antibody blog
 • anti-GCGR antibody blog
 • anti-TCEAL2 antibody blog
 • anti-GCH1 antibody blog
 • anti-NDUFA13 antibody blog
 • anti-KIAA1456 antibody blog
 • anti-CFL1 antibody blog
 • anti-uPAR antibody blog
 • anti-TLR8 antibody blog
 • anti-RFX6 antibody blog
 • anti-NET1 antibody blog
 • anti-USP4 antibody blog
 • anti-GCG antibody blog
separator
Blog Categories separator
separator
 • Assay Kit Blogs
 • Biochemical Blogs
 • cDNA Clone Blogs
 • Monoclonal Antibody Blogs
 • Polyclonal Antibody Blogs
 • Rec/Purified Protein Blogs
 • Popular Product Blogs
separator
Our Best Sellers moreseparator
separator
 • EP300 Antibody
 • granulin (GRN) Antibody
 • Interleukin 10 Receptor Beta (IL10Rb) Antibody
 • Cardiac myosin-light chains 1 (CMIC-1) ELISA Kit
 • Phospholipase A2, Lipoprotein Associated (LpPLA2) ELISA Kit
 • Anti-Survivin Antibody ELISA Kit
 • Urokinase-Type Plasminogen Activator Receptor (U-PAR) ELISA Kit
 • Phosphatidylinositol-4-phos phate 5-kinase type-1 gamma (PIP5... ELISA Kit
 • GRAP2 Antibody
 • CD226 antigen (CD226) ELISA Kit
 • angiotensin II (ANG-II) ELISA Kit
 • CD161 Antibody
 • Microtubule Associated Protein Tau (MAPtau) ELISA Kit
 • NDUFB6 Antibody
 downarrow more ...
separator

anti-IGF1 antibody product blog

separator
Posted on 2015-08-14 08:35:04 by mybiosource_staff
Share it on ...     
separator
separator
Tags: Antibody; IGF1; Polyclonal Antibody; anti-IGF1 antibody; insulin-like growth factor 1 receptor;
separator
The IGF1R igf1 (Catalog #MBS1491088) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human Insulin-like growth factor 1 receptor polyclonal Antibody, FITC reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Insulin-like growth factor 1 receptor can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). Researchers should empirically determine the suitability of the IGF1R igf1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The IGF1R igf1 product has the following accession number(s) (GI #11024682) (NCBI Accession #NP_000609.1) (Uniprot Accession #P05019). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:


Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R.

IGF1R igf1

horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions