|The IL-33 il33 (Catalog #MBS9413109) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The IL-33 Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s IL-33 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunofluorescence (IF). Researchers should empirically determine the suitability of the IL-33 il33 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The IL-33 il33 product has the following accession number(s) (GI #15559209) (NCBI Accession #NP_254274). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the IL-33 Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of IL-33 in human lymph node tissue lysate with IL-33 antibody at (A) 1 and (B) 2 ug/mL.)
Immunofluorescence (IF) (Immunofluorescence of IL-33 in human lymph node tissue with IL-33 antibody at 20 ug/mL.)
Interleukin-33 (IL-33) is a recently identified member of the IL-1 family of cytokines whose other members include IL-1a/beta, IL-1Ra and IL-18. Its receptor has been shown to be ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling and IL-1R accessory protein (IL-1RAcP). Receptor binding of IL-33 activates NF-kB and MAP kinases and induces the expression of TH2-associated cytokines such as IL-4, IL-5 and IL-6. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine. Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties.
Immunogen Type: Peptide
Immunogen Description: Raised against a 19 amino acid peptide from near the amino terminus of human IL-33. Target Name: IL-33. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing IL-33 are readily searchable from our website. Different antibodies against the same target such as IL-33 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.