|The IL10R alpha il10ra (Catalog #MBS837254) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The IL10R alpha antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s IL10R alpha can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).
WB: 1:500-1:1000. Researchers should empirically determine the suitability of the IL10R alpha il10ra for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The IL10R alpha il10ra product has the following accession number(s) (GI #222136575) (NCBI Accession #NP_001549.2) (Uniprot Accession #Q13651). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Rabbit polyclonal IL10R alpha antibody.
Biological Significance: This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Immunogen: IL10R alpha antibody was raised in Rabbit using the peptide sequence around phosphorylation site of Serine 319/Serine 323 (D-S(p)-G-F-G-S(p)-T) derived from Human IL-10R subunit alpha as the immunogen. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing IL10R alpha are readily searchable from our website. Different antibodies against the same target such as IL10R alpha may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Brain Diseases, Disease Models, Animal, Hemorrhage, Inflammation, Kidney Diseases, Liver Diseases, Lung Diseases, Lung Neoplasms, Necrosis, Skin Diseases are some of the diseases may be linked to IL10R alpha antibody. IL10R alpha also interacts with the following gene(s): IL10, IL10RB, IL22RA1, JAK1, STAT1, STAT3, STAT5A, STAT5B. Blood, Bone, Brain, Intestine, Lung, Pancreas, Pharynx, Skin, Tonsil, Vascular tissues are correlated with this protein.