anti-IL17A antibody product blog
Tags: Antibody; Polyclonal Antibody; anti-IL17A antibody; IL17A;
The IL17A il17a (Catalog #MBS2526747) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The IL17A Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s IL17A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). Researchers should empirically determine the suitability of the IL17A il17a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The IL17A il17a product has the following accession number(s) (GI #2498481) (NCBI Accession #Q16552.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the IL17A Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of extracts of N (normal), R (retinopathy of prematurity) and V (VEGF/rho transgenic mice), using IL17A antibody.)
Immunofluorescence (IF) (Immunofluorescent analysis of mouse eyeball using IL17A antibody.)
IL-17A is a cystine-linked homodimeric pro-inflammatory cytokine produced by Th17 cells, a distinct CD4+ T cell lineage (1, 2). IL-17A stimulates the production of the pro-inflammatory cytokines IL-1beta, TNF-alpha, and IL-6. IL-17A also induces production of the neutrophil chemoattractants IL-8, CXCL1, and CXCL6 thereby bridging adaptive and innate immunity (1, 2). IL-17A is intimately involved in mucosal immunity against bacterial infections (1, 3) and has a putative role in some autoimmune disorders (1, 4). IL-17A effects appear to be exerted primarily through binding to the IL-17RA (5). IL-17A binding induces production of cytokines, chemokines and other proteins through activation of the Erk1/2 MAP kinase, PI3K/Akt, p38, and NF-kappaB pathways (3, 4, 6). Phosphorylation of some Jaks and Stats has been observed.
Immunogen: Recombinant protein of human IL17A
Observed Molecular Weight: 18kDa. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-6077 / sc-6076 / sc-7927. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing IL17A are readily searchable from our website. Different antibodies against the same target such as IL17A may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.