|The IL6ST il6st (Catalog #MBS9201393) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Phospho-IL6ST (Y905) Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Phospho-IL6ST (Y905) can be used in a range of immunoassay formats including, but not limited to, Dot Blot (DB), ELISA (EIA).
DB~~1:500. Researchers should empirically determine the suitability of the IL6ST il6st for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The IL6ST il6st product has the following accession number(s) (GI #300244535) (NCBI Accession #NP_001177910.1) (Uniprot Accession #P40189). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Phospho-IL6ST (Y905) Antibody with the following immunoassay(s):
Dot Blot (DB) (Dot blot analysis of anti-Phospho-IL6ST-Y905 Phospho-specific Pab on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.)
IL6ST is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein.
Antigen Type: Synthetic Peptide. Antigen Source: HUMAN
Cellular Location: Isoform 1: Cell membrane; Single-pass type I membrane protein
Tissue Location: Found in all the tissues and cell lines examined (PubMed: 2261637). Expression not restricted to IL6 responsive cells (PubMed: 2261637). Expressed in blood serum (at protein level) (PubMed: 24629561). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing IL6ST are readily searchable from our website. Different antibodies against the same target such as IL6ST may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. IL6ST also interacts with the following gene(s): IL6, IL6R, JAK1, JAK2, LIF, OSM, PTPN11, SOCS3, STAT1, STAT3.