anti-INPP5B antibody product blog
Tags: Antibody; Polyclonal Antibody; INPP5B; anti-INPP5B antibody;
The INPP5B inpp5b (Catalog #MBS6011639) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The INPP5B (OCRL2, Type II Inositol 1,4,5-trisphosphate 5-phosphatase, 75kD Inositol Polyphosphate-5-phosphatase, Phosphoinositide 5-phosphatase, MGC65156, MGC71303) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s INPP5B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).Suitable for use in Western Blot. Researchers should empirically determine the suitability of the INPP5B inpp5b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The INPP5B inpp5b product has the following accession number(s) (GI #37590185) (NCBI Accession #AAH58932.1) (Uniprot Accession #P32019). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful. The amino acid sequence is listed below:
MDQSVAIQET LAEGEYCVIA VQGVLCEGDS RQSRLLGLVR YRLEHGGQEH ALFLYTHRRM AITGDDVSLD QIVPVSRDFT LEEVSPDGEL YILGSDVTVQ LDTAELSLVF QLPFGSQTRM FLHEVARACP GFDSATRDPE FLWLSRYRCA ELELEMPTPR GCNSALVTWP GYATIGGGGS NFDGLRPNGK GVPMDQSSRG QDKPESLQPR QNKSKSEITD MVRSSTITVS DKAHILSMQK FGLRDTIVKS HLLQKEEDYT YIQNFRFFAG TYNVNGQSPK ECLRLWLSNG IQAPDVYCVG FQELDLSKEA FFFHDTPKEE EWFKAVSEGL HPDAKYAKVK LIRLVGIMLL LYVKQEHAAY ISEVEAETVG TGIMGRMGNK GGVAIRFQFH NTSICVVNSH LAAHIEEYER RNQDYKDICS RMQFCQPDPS LPPLTISNHD VILWLGDLNY RIEELDVEKV KKLIEEKDFQ MLYAYDQLKI QVAAKTVFEG FTEGELTFQP TYKYDTGSDD WDTSEKCRAP AWCDRILWKG KNITQLSYQS HMALKTSDHK PVSSVFDIGV RVVNDELYRK TLEEIVRSLD KMENANIPSV SLSKREFCFQ NVKYMQLKVE SFTIHNGQVP CHFEFINKPD EESYCKQWLN ANPSRGFLLP DSDVEIDLEL FVNKTTATKL NSGEDKIEDI LVLHLDRGKD YFLSVSGNYL PSCFGSPIHT LCYMREPILD LPLETISELL AYLAAYCFET QLVTKSLI.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the INPP5B (OCRL2, Type II Inositol 1,4,5-trisphosphate 5-phosphatase, 75kD Inositol Polyphosphate-5-phosphatase, Phosphoinositide 5-phosphatase, MGC65156, MGC71303) with the following immunoassay(s):
Western Blot (WB) (Western Blot analysis of INPP5B expression in transfected 293T cell line by INPP5B polyclonal antibody. Lane 1: INPP5B transfected lysate (85kD). Lane 2: Non-transfected lysate.)
Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). INPP5B encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Immunogen: Full length human INPP5B, aa1-748 (AAH58932.1). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing INPP5B are readily searchable from our website. Different antibodies against the same target such as INPP5B may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.