Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
Fax 1.858.633.0166    Email 
menu1 Home Products Ordering Company Help menu7
   MyBioSource  rightarrow Polyclonal Antibody Blog  rightarrow anti-IRS1 antibody  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Blogs moreseparator
 • anti-METT5D1 antibody blog
 • anti-ANP32A antibody blog
 • anti-SEC13L1 antibody blog
 • anti-Gle1 antibody blog
 • anti-USP11 antibody blog
 • anti-AQP4 antibody blog
 • anti-CREG1 antibody blog
 • anti-Cdk9 antibody blog
 • anti-NEUROG3 antibody blog
 • anti-sgcg antibody blog
 • anti-JAM2 antibody blog
 • anti-ARHGEF7 antibody blog
 • anti-LRP130 antibody blog
 • anti-FBXO44 antibody blog
 • anti-SFRS12 antibody blog
 • anti-GATA1 antibody blog
 • anti-FKBP3 antibody blog
 • anti-Ptx3 antibody blog
 • anti-CCNB2 antibody blog
 • anti-EGF antibody blog
Blog Categories separator
 • Assay Kit Blogs
 • Biochemical Blogs
 • cDNA Clone Blogs
 • Monoclonal Antibody Blogs
 • Polyclonal Antibody Blogs
 • Rec/Purified Protein Blogs
 • Popular Product Blogs
Our Best Sellers moreseparator
 • Cyclic GMP Antibody
 • Histone H4 (HIST4H4) Antibody
 • a-Amino-b-methylaminopropio nic Acid, Hydrochloride Biochemical
 • Glyceraldehyde 3 Phosphate Dehydrogenase (GAPDH) ELISA Kit
 • I-Ek (public; Ia.m7) Antibody
 • Goat anti Human IgG, Heavy and Light Chain Specific Antibody... Secondary Antibody
 • chemokine (C-C motif) ligand 7 (CCL7) ELISA Kit
 • osteoclast associated, immunoglobulin-like receptor (OSCAR) ELISA Kit
 • Rat Anti-Mouse Lambda (lambda light chain specific) Secondary Antibody
 • Complement 3 split product (C3SP) ELISA Kit
 • ribonuclease, RNase A family, 1 (pancreatic) (RNASE1) ELISA Kit
 • NLR family, pyrin domain containing 3 (NLRP3) Antibody
 • SHH Antibody
 downarrow more ...

anti-IRS1 antibody product blog

Posted on 2017-03-04 01:29:18 by mybiosource_staff
Share it on ...     
Tags: Antibody; Polyclonal Antibody; IRS1; anti-IRS1 antibody; IRS-1 pre-CT;
The IRS1 irs1 (Catalog #MBS617982) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The IRS-1 pre-CT (Insulin Receptor Substrate 1) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s IRS-1 pre-CT can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP).
Suitable for use in Western Blot and Immunoprecipitation.
Dilution: Western Blot: 0.5-2ug/ml detected IRS-1 in a 3T3/A31 RIPA cell lysate.
Immunoprecipitation: 4ug immunoprecipitated IRS-1 from 500ug of a 3T3/A31 RIPA lysate.
Optimal dilution determined by the researcher. Researchers should empirically determine the suitability of the IRS1 irs1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The IRS1 irs1 product has the following accession number(s) (GI #5031805) (NCBI Accession #NP_005535.1) (Uniprot Accession #P35568). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

The insulin receptor substrate 1 (IRS1) is a major effector of insulin receptor action. Unlike other activated receptors (e.g., the EGF receptor and the PDGF receptor) which directly bind to multiple signalling proteins, the activated insulin receptor primarily binds only IRS1 and then phosphorylates it on multiple tyrosine residues. Phosphorylated IRS1 serves as the major agent of insulin receptor-mediated signal transduction by being bound by cytoplasmic signaling proteins containing SH2 domains. Numerous SH2-containing signaling proteins (e.g., Grb2, SH-PTP2/SYP, PI 3-kinase, and Nck) have been shown to preferentially bind to distinct tyrosine phosphorylation sites in IRS1. The specificity and coordination of insulin receptor signaling may result from competition of these signaling proteins for binding to IRS1.

IRS1 irs1

Immunogen: Precarboxy-terminal peptide (16aa) corresponding to aa1220-1235 of rat liver IRS-1 (KLH coupled). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing IRS1 are readily searchable from our website. Different antibodies against the same target such as IRS1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Breast Neoplasms, Diabetes Mellitus, Type 2, Fatty Liver, Hyperinsulinism, Hypertension, Inflammation, Insulin Resistance, Necrosis, Neoplasms, Obesity are some of the diseases may be linked to IRS-1 pre-CT (Insulin Receptor Substrate 1). Bone, Brain, Connective Tissue, Heart, Kidney, Liver, Muscle, Nerve, Ovary, Pancreas tissues are correlated with this protein.
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions