anti-ITGA8 antibody product blog
Tags: Antibody; Polyclonal Antibody; anti-ITGA8 antibody; ITGA8;
The ITGA8 itga8 (Catalog #MBS9209958) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ITGA8 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s ITGA8 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC).WB: ~~1:1000
IHC-P: ~~1:50~100. Researchers should empirically determine the suitability of the ITGA8 itga8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The ITGA8 itga8 product has the following accession number(s) (GI #49170034) (NCBI Accession #NP_003629.1) (Uniprot Accession #P53708). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the ITGA8 Antibody (C-term) with the following immunoassay(s):
Western Blot (WB) (ITGA8 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the ITGA8 antibody detected the ITGA8 protein (arrow).)
Immunohistochemistry (IHC) (ITGA8 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ITGA8 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.
Antigen Type: Synthetic Peptide. Antigen Source: HUMAN
Cellular Location: Membrane; Single-pass type I membrane protein Cell membrane
Tissue Location : Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and hepatic stellar cells and vascular and visceral smooth muscle (at protein level). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ITGA8 are readily searchable from our website. Different antibodies against the same target such as ITGA8 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. ITGA8 also interacts with the following gene(s): FN1, ITGB1, ITGB3, ITGB5, ITGB8.