anti-JAB1 antibody product blog
Tags: Antibody; Polyclonal Antibody; JAB1; anti-JAB1 antibody;
The JAB1 cops5 (Catalog #MBS178334) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-JAB1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s JAB1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin.Western Blot Concentration: 0.1-0.5ug/ml
Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml. Researchers should empirically determine the suitability of the JAB1 cops5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The JAB1 cops5 product has the following accession number(s) (GI #38027923) (NCBI Accession #NP_006828.2) (Uniprot Accession #Q92905). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-JAB1 Antibody with the following immunoassay(s):
Western Blot (WB) (Anti- JAB1 Picoband antibody, MBS178334, Western blotting
All lanes: Anti JAB1 (MBS178334) at 0.5ug/ml
Lane 1: Rat Testis Tissue Lysate at 50ug
Lane 2: Mouse Testis Tissue Lysate at 50ug
Lane 3: HELA Whole Cell Lysate at 40ug
Lane 4: 293T Whole Cell Lysate at 40ug
Predicted bind size: 38KD
Observed bind size: 38KD )
Immunohistochemistry (IHC) (Anti- JAB1 Picoband antibody, MBS178334, IHC(P)
IHC(P): Mouse Testis Tissue )
Immunohistochemistry (IHC) (Anti- JAB1 Picoband antibody, MBS178334, IHC(P)
IHC(P): Rat Testis Tissue )
Immunohistochemistry (IHC) (Anti- JAB1 Picoband antibody, MBS178334, IHC(P)
IHC(P): Human Mammary Cancer Tissue )
Description: Rabbit IgG polyclonal antibody for COP9 signalosome complex subunit 5(COPS5) detection. Tested with WB, IHC-P in Human;Mouse;Rat.
Background: COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis), also known as COPS5 or JAB1, is a gene conserved from humans to Saccharomyces cerevisiae. It is a member of the MOV34 family. COPS5 is mapped to 8q13.1. The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. COPS5 can interact with the cytoplasmic domain of the beta-2 subunit of the alpha-L/beta-2 integrin LFA1, and it is the only protein demonstrated to interact with MIF. COPS5, VHL, and TRC8 proteins appear to be linked both physically and functionally, and all 3 may participate in the development of kidney cancer. In addition to that, COPS5 is an essential cofactor for the apoptotic function of E2F1.
Immunogen: E Coli-derived human JAB1 recombinant protein (Position: M8-S334). Human JAB1 shares 99.4% amino acid (aa) sequence identity with mouse JAB1.
Ig Type: Rabbit IgG. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.